Institute for Computational Cancer Biology | Groups

Schwarzlab

Come on board!

We are looking for talented and motivated postdoctoral fellows and graduate students to join our team at one of our sites in Cologne or Berlin!

You will develop algorithms and/or spearhead the analysis of cancer genomics projects focused on chromosomal instability, cancer evolution and cancer gene regulation.

Ideal postdoc candidates will recently have obtained a PhD and have a strong background in computational biology, genomics or a related field and a strong interest in quantitative research. Prior experience in single-cell or cancer genomics is a plus.

Ideal PhD candidates will have a Masters degree in bioinformatics, physics, mathematics, computer science or a related field and some prior experience with analysing genomics data.

We also offer MD projects for physicians with an interest in quantitative research as well as opportunities for Bachelor or Master theses and internships. Please contact Roland directly.

Successful candidates should be enthusiastic about working in a highly interdisciplinary and collaborative environment.

Current openings

Schwarzlab - Cologne

PhD or Postdoc in Algorithms for Chromatin Architecture

About the project

Using the Genome Architecture Mapping (GAM) data, you will develop new algorithms for haplotype reconstruction and detection of structural variants in aneuploid genomes. You will apply these methods to cancer cell lines and other aneuploid model systems to gain new insights into how chromosomal instability affects chromatin structure. The project will be a collaboration with Prof. Dr Ana Pombo at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, who has developed GAM in her lab and who will provide the primary experimental data. You will work closely with an interdisciplinary and collaborative group of bioinformaticians and experimentalists within the DFG Priority Programme "Spatial Genome Architecture in Development and Disease" (SPP 2202).

About you

Ideal candidates will have a Masters or PhD degree in Physics, Mathematics, Computer Science, Bioinformatics or a related field, and a strong interest in quantitative and epigenetics research. Prior experience in method development or the analysis of chromatin structure data or other genomics data is a plus. Successful candidates should be enthusiastic about working in a highly interdisciplinary environment. Excellent communication skills and the ability to work in a team are required.

For further reading and our recent works see:

Markowski et al. 2021, Bioinformatics

Beagrie et al. 2017, Nature

 

About the position

You will work at the ICCB at the Medical Faculty and University Hospital of the University of Cologne. We offer a competitive salary according to German E13 TVL 100%. Contracts are limited to 3 years with the possibility of prolongation. For inquiries, please email roland.schwarz[at]uni-koeln.de. The positions are to be filled as soon as possible; applications will be considered initially until November 30.

Apply by email

Schwarzlab - Berlin

PhD or Postdoc in Single-cell Cancer Genomics and Evolution

About the project

Using state-of-the-art single-cell DNA sequence data (Strand-seq), you will develop new algorithms for haplotype reconstruction and somatic mutation detection in complex polyploid genomes. You will apply these methods to cancer cell lines and primary patient samples to gain new insights into the evolution of chromosomal instability and mutational processes during disease progression. The project will be a collaboration with Dr Ashley Sanders at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, who specializes in the development of single-cell multi-omic technologies and their application in clinical research. You will work closely with an interdisciplinary and collaborative group of bioinformaticians, clinicians, and experimentalists, to develop new methods with strong translational potential.

About you

Ideal candidates will have a Masters or PhD degree in Physics, Mathematics, Computer Science or related fields, and a strong interest in quantitative and genetic research. Prior experience in single-cell or cancer genomics is a plus. Successful candidates will show a strong work ethic and should be enthusiastic about working in a highly interdisciplinary environment. Excellent communication skills and the ability to work in a team are required.

For further reading and our recent works see:

Kaufmann et al. 2021, bioRxiv

Watkins et al. 2020, Nature

Sanders et al. 2020, Nature Biotech.

 

About the position

The position is based at the BIFOLD Berlin in collaboration with the Max Delbrück Center for Molecular Medicine. We offer a competitive salary according to German E13 TVL 100%. Contracts are limited to 3 years with the possibility of prolongation. For inquiries, please email roland.schwarz[at]uni-koeln.de and ashley.sanders[at]mdc-berlin.de. The positions are to be filled as soon as possible; applications will be considered initially until November 30.

Apply by email

Schwarzlab - Cologne

Scientific Programmer / Postdoc in Cancer Genomics

About the project

You will develop the next generation of algorithms for inferring and simulating cancer evolution and intra-tumour heterogeneity. You will provide research support to the group and help develop and maintain the group’s genomics pipelines, software tools and algorithms. The position offers ample opportunities for contributing your own ideas to the group and for developing and extending your own research profile. You will work closely with an interdisciplinary and collaborative group of bioinformaticians, clinicians, and experimentalists, to develop new methods with strong translational potential.

About you

Ideal candidates will have a PhD degree in Bioinformatics, Physics, Computer Science or related fields, and a background in software development and computational biology or genomics. Prior experience in cancer research is a plus. Successful candidates will show a strong work ethic and should be enthusiastic about working in a highly interdisciplinary environment. Excellent communication skills and the ability to work in a team are required.

For further reading and our recent works see:

Kaufmann et al. 2021, bioRxiv

Watkins et al. 2020, Nature

PCAWG TCG et al. 2020, Nature.

 

About the position

The position will be placed at the ICCB at the Medical Faculty and University Hospital of the University of Cologne. We offer a competitive salary according to German E13 TVL 100%. Contracts are limited to 2 years with the possibility of prolongation. For inquiries, please email roland.schwarz[at]uni-koeln.de. The positions are to be filled as soon as possible; applications will be considered initially until November 30.

Apply by email

Want to know more?

You are uncertain if your professional profile would be a good fit? There seem to be currently no open positions?

We will always consider applications from outstanding candidates.

In this case, please send your application as a single PDF via email to Prof. Roland Schwarz. Applications should include:

  1. Cover letter stating your general career objectives and research interests
  2. CV with publication list
  3. Names and contact information of three references