Welcome to the

Institute for Computational Cancer Biology

at the University Hospital and the Medical Faculty of the University of Cologne.

Mission and Goals

Data science and algorithms for cancer research

The Institute for Computational Cancer Biology (ICCB) at the University Hospital Cologne was founded in 2022 to advance cancer research through computational methods and to train and educate the next generation of computational cancer scientists. 

We are part of the Cancer Research Center Cologne Essen (CCCE) funded by the Ministry of Culture and Science of the State of North Rhine-Westphalia.

Our mission is to develop bespoke statistical methods, machine learning approaches, algorithms and models to decipher tumour heterogeneity and cancer evolution and improve our understanding of the wealth of genomic, transcriptomic, epigenomic and imaging data collected in cancer research.

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▶ Research spotlights ▶ Work with us

About us


April 25, 2024

Model for transcription-based lung cancer risk prediction published in Genome Medicine

We are glad to announce that our computational model to assess lung cancer risk from non-invasive nasal swabs of healthy volunteers and lung cancer patients was published in Genome Medicine.

By using a transcriptional network approach we were able to demonstrate a causal relationship of de-regulated immune-pathway expression and  lung cancer risk.

Our lung cancer risk classifier based on transcriptomic data derived from nasal swabs provides initial evidence for germline-mediated personalized smoke injury response and risk in the general population, with potential implications for managing long-term lung cancer incidence and mortality.

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October 25, 2022

Multiple job openings in the Schwarzlab

The Schwarzlab at the ICCB has multiple job openings for PhD students, Postdoctoral Fellows and a Scientific Programmer in multiple national and international projects working on chromosomal instability, copy-number evolution and algorithms for tumour heterogeneity. 

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September 20, 2022

The Lehmann Lab joins the ICCB

We are glad that the Lehmann Lab has joined the ICCB as an associated group. 

The Lehmann Lab is interested in the development of approaches that support the molecular characterisation of patient cohorts and in approaches for data integration to gain insights into disease mechanisms. Welcome on board!

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Research Spotlights

Schwarz Lab - Cologne/Berlin

Cancer Genomics and Evolution

Algorithms for inferring and simulating cancer evolution and for understanding tumour heterogeneity, with a special focus on chromosomal instability and somatic copy-number alterations.

Lehmann Lab - Aachen

Molecular Signatures and Data Integration

Approaches that support the molecular characterisation of patient cohorts and reveal disease mechanisms through integration of diverse types of molecular data.


Sponsors and Partners


University Hospital and University of Cologne


Cancer Research Center Cologne Essen (CCCE)

funded by the Ministry of Culture and Science of the State of North Rhine-Westphalia.


Strategic partner

Berlin Institute for the Foundations of Learning and Data (BIFOLD)

funded by the German Ministry for Research and Education (BMBF).